Beilstein J. Org. Chem.2010,6, No. 11, doi:10.3762/bjoc.6.11
Diels–Alder reactions involving 1-oxa-1,3-butadienes.
Keywords: β-haloaldehydes; hetero Diels–Alder reaction; 1-oxa-1,3-butadiene; pyrido[2,3-d]pyrimidines; uracil; Introduction
The importance of uracil and its annulated derivatives is well recognized by synthetic as well as biological chemists [1][2
dihydropyrans [36][37][38].
Heterocyclic β-haloaldehydes are very interesting compounds which can be transformed in a number of ways to fused heterocycles [39][40] by using the reactivity of halide for nucleophilic substitution in combination with a multitude of transformation possibilities from the aldehyde
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Graphical Abstract
Scheme 1:
Stereoselective synthesis of some new complex annulated pyrido[2,3-d]pyrimidines by intramolecular ...